3-FLUORO-2-METHYLPYRIDINE

Base Information

• Chemical Name: 3-FLUORO-2-METHYLPYRIDINE
• CAS No.: 15931-15-4
• Molecular Formula: C₆H₆FN
• Molecular Weight: 111.119
• Hs Code.: 2933399090
• Mol file: 15931-15-4.mol

Synonyms:2-Picoline,3-fluoro- (8CI);3-Fluoro-2-methylpyridine;3-Fluoro-2-picoline;

Chemical Property of 3-FLUORO-2-METHYLPYRIDINE

Chemical Property:

• Vapor Pressure: 24.2mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 113.872 °C at 760 mmHg
• PKA: 3.53±0.10(Predicted)
• Flash Point: 22.669 °C
• PSA: 12.89000
• Density: 1.077 g/cm³
• LogP: 1.52910
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99.5% ^*data from raw suppliers

3-Fluoro-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-2-methylpyridine was used in the synthesis of fluorine-containing pyridinealdoximes of potential use for the reactivation of cholinesterase.

Technology Process of 3-FLUORO-2-METHYLPYRIDINE

There total 5 articles about 3-FLUORO-2-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-methyl-3-pyridinamine (3430-10-2) → 3-fluoro-2-methylpyridine (15931-15-4)

Guidance literature:

With tetrafluoroboric acid; ethyl nitrite;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 3-fluoro-2-methylpyridine (15931-15-4)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid

2: hydrogenchloride; sodium nitrite

3: phosphorus pentachloride; trichlorophosphate

4: palladium on carbon; hydrogen

5: tetrafluoroboric acid; ethyl nitrite

With hydrogenchloride; tetrafluoroboric acid; ethyl nitrite; phosphorus pentachloride; sulfuric acid; palladium on carbon; hydrogen; nitric acid; sodium nitrite; trichlorophosphate; 5: Balz-Schiemann reaction;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield:

6-chloro-4-methyl-3-nitropyridine (22280-60-0) → 3-fluoro-2-methylpyridine (15931-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen

2: tetrafluoroboric acid; ethyl nitrite

With tetrafluoroboric acid; ethyl nitrite; palladium on carbon; hydrogen; 2: Balz-Schiemann reaction;

DOI:10.1016/j.jfluchem.2011.05.028

upstream raw materials:

2-Amino-6-methylpyridine

2-methyl-3-pyridinamine

6-chloro-4-methyl-3-nitropyridine

6-methyl-5-nitropyridin-2-ol

Downstream raw materials:

3-fluoropyridine-2-carbaldehyde oxime

3-fluoropyridine-2-carbaldehyde

3-fluoro-2-methylpyridine 1-oxide

Refernces

• 1、 Timperley, Christopher M.,Banks, R. Eric,Young, Ian M.,Haszeldine, Robert N.. "Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning". . p. 541 - 547. Retrieved 2011/09/15.