4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate

Base Information

Chemical Name:4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate
CAS No.:1613590-70-7
Molecular Formula:C₂₂H₂₉FN₃O₉PS
Molecular Weight:561.525
Hs Code.:

Synonyms:4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate

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Chemical Property of 4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate

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Technology Process of 4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate

There total 14 articles about 4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.5%

: 261909-49-3
phenyl(isopropoxy-L-alaninyl) phosphorochloridate

: 1613589-05-1
1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

: 1613590-70-7
4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate

Guidance literature:: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione; With isopropylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

phenyl(isopropoxy-L-alaninyl) phosphorochloridate; In tetrahydrofuran; at 20 - 37 ℃;

Reference yield: 12.5%

: 1365255-67-9
(O-phenyl-N-(S)-1-(isopropoxycarbonyl)eth-1-yl)thiophosphoramidic chloride

: 1613589-05-1
1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

: 1613590-70-7
4'-fluoro-2'-methyluridine-5'-(O-phenyl)-N-(S)-1-(isopropoxycarbonyl)ethyl thiophosphoramidate

Guidance literature:: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione; With isopropylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

(O-phenyl-N-(S)-1-(isopropoxycarbonyl)eth-1-yl)thiophosphoramidic chloride; In tetrahydrofuran; at 20 - 37 ℃;