<4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

Base Information

Chemical Name:<4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide
CAS No.:131490-79-4
Molecular Formula:C₁₅H₂₀N₂O₃
Molecular Weight:276.335
Hs Code.:

Synonyms:<4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

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Technology Process of <4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

There total 3 articles about <4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 88072-83-7
<5(S,R),4(S,R)>-5-(4-methoxyphenyl)-4-methyl-N-tert-butylisoxazolinecarboxamide

: 131490-79-4
<4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/jo00005a042

Reference yield:

: 88072-78-0
N-tert-butyl-2-(hydroxyimino)butanamide

: 131490-79-4
<4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TMEDA, n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) -78 deg C

2: 67 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; boron tribromide; In dichloromethane;
DOI:10.1021/jo00005a042

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 131490-79-4
<4(S,R),5(S,R)>-5-(4-hydroxyphenyl)-4-methyl-N-tert-butylisoxazolecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TMEDA, n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) -78 deg C

2: 67 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; boron tribromide; In dichloromethane;
DOI:10.1021/jo00005a042