1-(3-NITRO-PHENYL)-ETHYLAMINE

Base Information

• Chemical Name: 1-(3-NITRO-PHENYL)-ETHYLAMINE
• CAS No.: 90271-37-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2921499090
• Mol file: 90271-37-7.mol

Synonyms:Benzylamine,a-methyl-m-nitro- (6CI,7CI);1-(3-Nitrophenyl)ethylamine;

Chemical Property of 1-(3-NITRO-PHENYL)-ETHYLAMINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 264.8 °C at 760 mmHg
• PKA: 8.51±0.10(Predicted)
• Flash Point: 113.9 °C
• PSA: 71.84000
• Density: 1.199g/cm³
• LogP: 2.83800
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

1-(3-Nitrophenyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-NITRO-PHENYL)-ETHYLAMINE

There total 19 articles about 1-(3-NITRO-PHENYL)-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-1-(3-mitrophenyl)ethan-1-one O-methyl oxime (72278-09-2) → 3-nitro-α-methylbenzylamine (90271-37-7,297730-25-7)

Guidance literature:

With sodium tetrahydroborate; zirconium(IV) chloride; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01297

Reference yield: 95.0%

m-nitroacetophenone oxime (7471-32-1) → 3-nitro-α-methylbenzylamine (90271-37-7,297730-25-7)

Guidance literature:

With sodium hydrogensulfate monohydrate; molybdenum(V) chloride; sodium cyanoborohydride; In ethanol; for 2h; Reflux;

DOI:10.5012/bkcs.2011.32.9.3323

Reference yield: 92.0%

(S)-1-(1-azidoethyl)-3-nitrobenzene (317830-26-5) → (S)-1-(3 -nitrophenyl)ethan-1-amine (90271-37-7,297730-25-7)

Guidance literature:

With triphenylphosphine; In water; toluene; at 80 ℃; for 3h;

upstream raw materials:

formamide

3-Nitroacetophenone

1-(1-azidoethyl)-3-nitrobenzene

m-nitroacetophenone oxime

Downstream raw materials:

(S)-1-(3 -nitrophenyl)ethan-1-amine

(R)-1-(3-nitro-phenyl)-ethylamine

N-(1-(3-nitrophenyl)ethyl)carbamic acid t-butyl ester

C₂₃H₂₆N₄O₅