2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide

Base Information

• Chemical Name: 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide
• CAS No.: 1355342-87-8
• Molecular Formula: C₂₄H₁₉Cl₂F₃N₄O₂
• Molecular Weight: 523.342
• Mol file: 1355342-87-8.mol

Synonyms:2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide

Chemical Property of 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide

There total 6 articles about 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-[2-(3-azetidinyloxy)-6-(trifluoromethyl)-3-pyridinyl]-2-chloro-4-pyridinecarboxamide (1355345-56-0) + (E)-4-chlorostyrylboronic acid (154230-29-2) → 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide (1355342-87-8)

Guidance literature:

formaldehyd; N-[2-(3-azetidinyloxy)-6-(trifluoromethyl)-3-pyridinyl]-2-chloro-4-pyridinecarboxamide; In 1,4-dioxane; at 90 ℃; for 1h;

(E)-4-chlorostyrylboronic acid; In 1,4-dioxane; at 90 ℃; for 4h;

Reference yield:

1,1-dimethylethyl 3-[[3-nitro-6-(trifluoromethyl)-2-pyridinyl]oxy]-1-azetidinecarboxylate (1355345-53-7) → 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide (1355342-87-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium chloride / iron / ethanol; water / 4 h / Reflux

2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

3.1: acetyl chloride; methanol / 6 h / 0 - 20 °C

4.1: 1,4-dioxane / 1 h / 90 °C

4.2: 4 h / 90 °C

With methanol; ammonium chloride; triethylamine; acetyl chloride; iron; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

3-amino-2-chloro-6-(trifluoromethyl)pyridine (117519-09-2) → 2-chloro-N-[2-[[1-[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]-3-azetidinyl]oxy]-6-(trifluoromethyl)-3-pyridinyl]-4-pyridinecarboxamide (1355342-87-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid; dihydrogen peroxide / 20 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3.1: ammonium chloride / iron / ethanol; water / 4 h / Reflux

4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

5.1: acetyl chloride; methanol / 6 h / 0 - 20 °C

6.1: 1,4-dioxane / 1 h / 90 °C

6.2: 4 h / 90 °C

With methanol; sulfuric acid; dihydrogen peroxide; potassium carbonate; ammonium chloride; triethylamine; acetyl chloride; iron; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

formaldehyd

N-[2-(3-azetidinyloxy)-6-(trifluoromethyl)-3-pyridinyl]-2-chloro-4-pyridinecarboxamide

(E)-4-chlorostyrylboronic acid

3-amino-2-chloro-6-(trifluoromethyl)pyridine