2,4,6-Tris(trifluoromethyl)aniline

Base Information

Chemical Name:2,4,6-Tris(trifluoromethyl)aniline
CAS No.:25753-22-4
Molecular Formula:C9H4 F9 N
Molecular Weight:297.123
Hs Code.:2921420090
DSSTox Substance ID:DTXSID00380758
Nikkaji Number:J940.907F
Wikidata:Q82171190
Mol file:25753-22-4.mol

Synonyms:2,4,6-tris(trifluoromethyl)aniline;25753-22-4;MFCD01312617;2,4,6-Tris-trifluoromethyl-phenylamine;SCHEMBL394903;DTXSID00380758;QIDUETMNCXXNKY-UHFFFAOYSA-N;AKOS017344579;2',4',6'-Tris-(trifluormethyl)-anilin;FT-0609930;A817998;SR-01000414352;SR-01000414352-1

Suppliers and Price of 2,4,6-Tris(trifluoromethyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,4,6-Tris(trifluoromethyl)aniline
50mg
$ 660.00

Medical Isotopes, Inc.
2,4,6-Tris(trifluoromethyl)aniline
250 mg
$ 675.00

Matrix Scientific
2,4,6-Tris(trifluoromethyl)aniline 97%
1g
$ 828.00

CHESS?
MC003081:2,4,6-Tris-trifluoromethyl-phenylamine 95
1 g
$ 336.00

Atlantic Research Chemicals
2,4,6-Tris(trifluoromethyl)aniline 95%
1gm:
$ 459.49

American Custom Chemicals Corporation
2,4,6-TRIS(TRIFLUOROMETHYL)ANILINE 95.00%
1G
$ 682.27

Alichem
2,4,6-Tris(trifluoromethyl)aniline
1g
$ 998.00

AK Scientific
2,4,6-Tris(trifluoromethyl)aniline
1g
$ 1167.00

AHH
2,4,6-tris(Trifluoromethyl)aniline 97%
1g
$ 340.00

Total 9 raw suppliers

Chemical Property of 2,4,6-Tris(trifluoromethyl)aniline

Chemical Property:

Vapor Pressure:3.97mmHg at 25°C
Melting Point:57-59
Refractive Index:1.388
Boiling Point:149.8°C at 760 mmHg
Flash Point:55.5°C
PSA：26.02000
Density:1.545g/cm³
LogP:4.90640
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:0
Exact Mass:297.02000259
Heavy Atom Count:19
Complexity:291

Purity/Quality:

97% ^*data from raw suppliers

2,4,6-Tris(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C(=C1C(F)(F)F)N)C(F)(F)F)C(F)(F)F
Uses 2,4,6-Tris(trifluoromethyl)aniline, is a Fluorinated substituents that have become valuable tool in medical chemistry. It can also be used for the preparation of azo dyes containing fluorine.

Technology Process of 2,4,6-Tris(trifluoromethyl)aniline

There total 6 articles about 2,4,6-Tris(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 25753-21-3
2,4,6-Tris-(trifluormethyl)-benzamid

: 25753-22-4
2,4,6-tris(trifluoromethyl)aniline

Guidance literature:: With potassium hydroxide; bromine; at 0 ℃; for 12h;
DOI:10.1016/S0022-1139(97)00097-3

Reference yield: 55.0%

: 1416438-86-2
1-iodo-2,4,6-tris(trifluoromethyl)benzene

: 25753-22-4
2,4,6-tris(trifluoromethyl)aniline

Guidance literature:: With copper(I) oxide; sodium azide; In dimethyl sulfoxide; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0032-1316809

Reference yield:

: 729-81-7
1,3,5-tris(trifluoromethyl)benzene

: 25753-22-4
2,4,6-tris(trifluoromethyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / n-BuLi / hexane; diethyl ether / 1.) -5 deg C, 2.) 2 h

2: 85 percent / PCl₅ / CCl₄ / 1 h / Heating

3: 90 percent / NH₃ / acetone / 12 h / Heating

4: 75 percent / Br₂, aq. KOH / 12 h / 0 °C

With potassium hydroxide; n-butyllithium; phosphorus pentachloride; ammonia; bromine; In tetrachloromethane; diethyl ether; hexane; acetone;
DOI:10.1016/S0022-1139(97)00097-3