methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate

Base Information

• Chemical Name: methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate
• CAS No.: 1416134-74-1
• Molecular Formula: C₂H₂O₄*C₁₄H₂₀N₂O₃
• Molecular Weight: 354.36
• Mol file: 1416134-74-1.mol

Synonyms:methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate

Chemical Property of methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate

There total 1 articles about methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.7%

5-benzyloxyiminopiperidine-2S-carboxylic acid methyl ester + oxalic acid (144-62-7,97993-78-7) → methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate (1416134-74-1)

Guidance literature:

5-benzyloxyiminopiperidine-2S-carboxylic acid methyl ester; With sulfuric acid; In ethyl acetate; at -20 - -15 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In ethyl acetate; at -20 - -15 ℃; for 5h;

oxalic acid; In methanol; ethyl acetate; at 45 ℃; for 2h;

Reference yield: 99.2%

methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate (1416134-74-1) → 5-benzyloxyiminopiperidine-2S-carboxylic acid methyl ester

Guidance literature:

methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate; With sodium hydroxide; In methanol; water; ethyl acetate; 1,2-dichloro-benzene; at 0 - 5 ℃; for 3h;

With dihydrogen peroxide; at 30 - 35 ℃; for 3h;

Reference yield: 99.0%

methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate (1416134-74-1) → (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide (1416134-49-0)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

upstream raw materials:

oxalic acid

Downstream raw materials:

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt

(2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide

Refernces