2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester

Base Information

• Chemical Name: 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester
• CAS No.: 102697-47-2
• Molecular Formula: C₁₀H₉FN₂O₂
• Molecular Weight: 208.192
• Mol file: 102697-47-2.mol

Synonyms:2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester

Chemical Property of 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester

There total 5 articles about 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 2-(4-fluorophenyl)acetate (587-88-2) → 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester (102697-47-2)

Guidance literature:

With 4-toluenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.8b02091

Reference yield: 83.0%

diazoacetic acid ethyl ester (623-73-4) + 4-fluoro-1-iodobenzene (352-34-1) → 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester (102697-47-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine; silver carbonate; In toluene; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02522

Reference yield: 83.0%

ethyl 2-diazo-3-oxobutanoate (2009-97-4) + 4-fluoro-1-iodobenzene (352-34-1) → 2-(4-fluorophenyl)-2-diazoacetic acid ethyl ester (102697-47-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In ethanol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201407653

upstream raw materials:

4-flourophenylmagnesium bromide

ethyl 2-(4-fluorophenyl)acetate

ethyl 2-diazo-3-oxobutanoate

4-fluoro-1-iodobenzene

Downstream raw materials:

1-(4-Fluoro-phenyl)-2,2-dimethyl-3-methylene-cyclopropanecarboxylic acid ethyl ester

1-(4-Fluoro-phenyl)-2-isopropylidene-cyclopropanecarboxylic acid ethyl ester

ethyl 3,3,3-trifluoro-2-(4-fluorophenyl)propanoate

ethyl 2-(4-fluorophenyl)-2-(4-methoxyphenyl)acetate