5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Base Information

Chemical Name:5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
CAS No.:220630-14-8
Molecular Formula:C₅₃H₆₈O₇Si
Molecular Weight:845.204
Hs Code.:

5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Synonyms:5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Suppliers and Price of 5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

There total 12 articles about 5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40547-58-8
N-(4-acetyl-3-hydroxyphenyl)acetamide

: 220630-14-8
5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / K₂CO₃ / dimethylformamide / 5 h / 20 °C

2: 81 percent / HCl, H₂O / 100 °C

3: 1.) NaNO₂ / 1.) H₂O, 0 deg C, 15 min, 2.) H₂O, 0 deg C, 15 min

5: 78 percent / MeI / 17 h / 130 °C

6: 97 percent / CuI, pyrrolidine / 2(dba)3> / 20 °C

7: 97 percent / MeI / 17 h / 130 °C

8: CuI, pyrrolidine / 2(PPh₃)2> / 20 °C

With pyrrolidine; hydrogenchloride; copper(l) iodide; water; potassium carbonate; sodium nitrite; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3773(19981204)37:22<3154::AID-ANIE3154>3.0.CO;2-W

Reference yield:

: 6089-09-4
4-pentynoic acid

: 220630-14-8
5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / DCC, DMAP / CH₂Cl₂ / 20 °C

2: 100 percent / TosOH / ethanol / 1 h / 20 °C

3: CuI, pyrrolidine / 2(PPh₃)2> / 20 °C

With pyrrolidine; dmap; copper(l) iodide; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane;
DOI:10.1002/(SICI)1521-3773(19981204)37:22<3154::AID-ANIE3154>3.0.CO;2-W

Reference yield:

: 58-22-0
testosterone

: 220630-14-8
5-{3-(2-Ethoxy-ethoxy)-4-[3-(2-ethoxy-ethoxy)-4-trimethylsilanylethynyl-phenylethynyl]-phenyl}-pent-4-ynoic acid (8R,9S,10R,13S,14S,17S)-3-ethoxy-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / DCC, DMAP / CH₂Cl₂ / 20 °C

2: 100 percent / TosOH / ethanol / 1 h / 20 °C

3: CuI, pyrrolidine / 2(PPh₃)2> / 20 °C

With pyrrolidine; dmap; copper(l) iodide; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane;
DOI:10.1002/(SICI)1521-3773(19981204)37:22<3154::AID-ANIE3154>3.0.CO;2-W