3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester
• CAS No.: 129648-73-3
• Molecular Formula: C₂₆H₃₀O₃
• Molecular Weight: 390.522
• Mol file: 129648-73-3.mol

Synonyms:3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester

Chemical Property of 3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester

There total 1 articles about 3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-isopropyl-2-oxo-2H-cycloheptafuran-3-carboxylate (106021-18-5) + 6-benzyloxy-1-hexanal (101492-91-5) → 3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester (129648-73-3)

Guidance literature:

With morpholine;

DOI:10.1021/jm00171a004

Reference yield: 60.0%

3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester (129648-73-3) → methyl 3-(4-benzyloxybutyl)-6-(1-hydroxyethyl-1-methyl)azulene-1-carboxylate

Guidance literature:

With oxygen; potassium acetate; In N,N-dimethyl-formamide; at 120 ℃; for 12h;

DOI:10.1055/s-1994-25706

Reference yield:

3-(4-Benzyloxy-butyl)-6-isopropyl-azulene-1-carboxylic acid methyl ester (129648-73-3) → 6-Isopropyl-3-[4-(benzenesulfonylamino)butyl]-azulene-1-carboxylic acid (129648-87-9)

Guidance literature:

Multi-step reaction with 5 steps

1: AlCl₃ / various solvent(s) / 0 °C

2: 96.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 12 h / Ambient temperature

3: hydrazine hydrate / ethanol / 2 h / Heating

4: aq. NaHCO₃ / acetone / 0.5 h / 0 °C

5: 83.6 percent / 10percent aq. NaOH / methanol / 4 h / Heating

With sodium hydroxide; aluminium trichloride; sodium hydrogencarbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; acetone;

DOI:10.1021/jm00059a001

upstream raw materials:

methyl 6-isopropyl-2-oxo-2H-cycloheptafuran-3-carboxylate

6-benzyloxy-1-hexanal

Downstream raw materials:

6-Isopropyl-3-[4-(benzenesulfonylamino)butyl]-azulene-1-carboxylic acid

N-[4-(3-Dimethylaminomethyl-6-isopropyl-azulen-1-yl)-butyl]-benzenesulfonamide

1-(cyanomethyl)-3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene

methyl 3-<4-<(phenylsulfonyl)amino>butyl>-6-isopropylazulene-1-carboxylate