1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

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Chemical Name:1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone
CAS No.:1315321-01-7
Molecular Formula:C₁₉H₂₀N₂O₃
Molecular Weight:324.379
Hs Code.:

Synonyms:1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

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Chemical Property of 1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

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Technology Process of 1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

There total 3 articles about 1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1315320-92-3
1,1'-(3-(but-2-yn-1-yl)-4-methyl-2-oxo-6-phenyl-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone

: 1315321-01-7
1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

Guidance literature:: With gold(III) tetrachloride trihydrate; In 1,2-dichloro-ethane; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol2015658

Reference yield:

: 879343-62-1
1,1'-(4-methyl-2-oxo-6-phenyl-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone

: 1315321-01-7
1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2: gold(III) tetrachloride trihydrate / 1,2-dichloro-ethane / 18 h / 80 °C / Inert atmosphere

With gold(III) tetrachloride trihydrate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Mitsunobu reaction;
DOI:10.1021/ol2015658

Reference yield:

: 25652-50-0
5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

: 1315321-01-7
1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / acetonitrile / 2 h / 130 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

3: gold(III) tetrachloride trihydrate / 1,2-dichloro-ethane / 18 h / 80 °C / Inert atmosphere

With dmap; gold(III) tetrachloride trihydrate; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; 2: Mitsunobu reaction;
DOI:10.1021/ol2015658