25652-50-0

Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenylis used as a starting material for the synthesis of various drugs and compounds. Its unique structure and properties make it a valuable component in the development of new pharmaceuticals with potential therapeutic applications.
Used in Medicinal Chemistry Research:
2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenylis used as a research tool in medicinal chemistry to explore its antihypertensive, anxiolytic, and neuroprotective properties. Further studies on its biological activities can lead to the discovery of new therapeutic agents for the treatment of various diseases and conditions.
Used in Organic Synthesis:
2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenylis used as a key intermediate in the synthesis of complex organic compounds. Its versatile structure allows for various chemical reactions, making it a valuable building block in the preparation of a wide range of organic molecules.

Upstream product

• 581-55-5 benzylidene 1,1-diacetate 
• 57-13-6 urea 
• 123-54-6 acetylacetone 
• 4657-12-9 sodium hydroxy(phenyl)methanesulfonate 
• 807334-29-8 urea phosphate 
• 100-52-7 benzaldehyde 
• 75-07-0 acetaldehyde 
• 93-91-4 1-phenylbutan-1,3-dione 
• 17356-08-0 thiourea 
• 105-45-3 acetoacetic acid methyl ester 
• 141-97-9 ethyl acetoacetate 
• 100-51-6 benzyl alcohol 
• 21351-39-3 monocarbamide dihydrogen sulfate 
• 100-44-7 benzyl chloride 

Downstream Products

• 502698-44-4 5-acetyl-1-ethyl-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one 
• 133893-87-5 5-acetyl-6-methyl-4-phenylpyrimidin-2(1H)-one 
• 879343-62-1 1,1'-(4-methyl-2-oxo-6-phenyl-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone 
• 1315320-92-3 1,1'-(3-(but-2-yn-1-yl)-4-methyl-2-oxo-6-phenyl-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone 
• 1315320-93-4 1,1'-(4-methyl-2-oxo-6-phenyl-3-(3-(trimethylsilyl)prop-2-yn-1-yl)-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone 
• 1315321-15-3 1,1'-(4-methyl-2-oxo-6-phenyl-3-(prop-2-yn-1-yl)-2,3-dihydropyrimidine-1,5(6H)-diyl)diethanone 
• 1315320-84-3 5-acetyl-1-(but-2-yn-1-yl)-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1315320-85-4 5-acetyl-6-methyl-4-phenyl-1-(3-(trimethylsilyl)prop-2-yn-1-yl)-3,4-dihydropyrimidin-2(1H)-one 
• 1315320-97-8 4-acetyl-6-methyl-3-phenyl-2,3,7,8-tetrahydro-1H-pyrido[1,2-c]pyrimidin-1-one 
• 1315320-98-9 methyl 1-oxo-3-phenyl-6-(trimethylsilyl)-2,3,7,8-tetrahydro-1H-pyrido[1,2-c]pyrimidine-4-carboxylate 
• 1315321-01-7 1,1'-(6-methyl-1-oxo-3-phenyl-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone 
• 1315321-02-8 1,1'-(1-oxo-3-phenyl-6-(trimethylsilyl)-7,8-dihydro-1H-pyrido[1,2-c]pyrimidine-2,4(3H)-diyl)diethanone 
• 728004-10-2 C₁₃H₁₆N₂O 

Relevant academic research and scientific papers

Synthesis of various ferrite (MFe2O4) nanoparticles and their application as efficient and magnetically separable catalyst for biginelli reaction

Herein, we reports the application of various spinel ferrite nanoparticles, MFe2O4 (M = Co, Ni, Cu, Zn), as efficient catalyst for Biginelli reaction. All ferrite nanoparticles were synthesized using a novel aqueous solution based me

Synthesis of Chiral 3,4-Dihydropyrimidin-2(1H)-one Derivatives and Their Stereoselective Chlorination with Chlorine Dioxide

Optically active derivatives of 3,4-dihydropyrimidin-2(1H)-one have been synthesized on the basis of myrtenal and methyl 2,3-O-isopropylidene-α-L-erythro-pentodialdo-1,4-furanoside in 45 and 50% yields, respectively, and subjected to stereoselective chlor

Synthesis of Glycoluril using Urea Phosphate

Abstract: Glycolurils are building blocks for the synthesis of cucurbiturils that are important host materials for several applications. Glycolurils are prepared conveniently by the condensation of 1,2-diketones with urea using an acid as catalyst. Herein, we report a facile method of synthesis of various glycolurils using urea phosphate and 1,2-diketones.

Synthesis method of dihydropyrimidinone compound

The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a

Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq

CoNiFe2O4@Silica-SO3H nanoparticles: New recyclable magnetic nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions

A useful and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were achieved by one-pot cyclocondensation between substituted aryl aldehydes, diketone/ketoester, and urea/thiourea using magnetic CoNiFe2O4@Silica-

Synthesis and characterization of nano acid catalyst derived from rice husk silica and its application for the synthesis of 3,4-dihydropyrimidinones/thiones compounds

In the present work, the extraction of silica nanoparticles from the rice husk followed by the modification using an acidic ionic liquid containing imidazolium butyl sulfonic acid through a sol-gel method (RH@[SiPrImBuSO3H]Cl) has been investig

Highly Efficient Synthesis of Substituted 3,4-Dihydropyrimidin-2-(1H)-ones (DHPMs) Catalyzed by Hf(OTf)4: Mechanistic insights into reaction pathways under metal Lewis acid catalysis and solvent-free conditions

In our studies on the catalytic activity of Group IVB transition metal Lewis acids, Hf(OTf)4 was identified as a highly potent catalyst for”one-pot, three-component” Biginelli reaction. More importantly, it was found that solvent-free conditions, in contrast to solvent-based conditions, could dramatically promote the Hf(OTf)4-catalyzed formation of 3,4-dihydro-pyrimidin-2-(1H)-ones. To provide a mechanistic explanation, we closely examined the catalytic effects of Hf(OTf)4 on all three potential reaction pathways in both “sequential bimolecular condensations” and “one-pot, three-component” manners. The experimental results showed that the synergistic effects of solvent-free conditions and Hf(OTf)4 catalysis not only drastically accelerate Biginelli reaction by enhancing the imine route and activating the enamine route but also avoid the formation of Knoevenagel adduct, which may lead to an undesired byproduct. In addition, 1H-MMR tracing of the H-D exchange reaction of methyl acetoacetate in MeOH-d4 indicated that Hf(IV) cation may significantly accelerate ketone-enol tautomerization and activate the β-ketone moiety, thereby contributing to the overall reaction rate.

Preparation method and application of novel ionic salicylaldehyde Schiff base zirconium complex (by machine translation)

The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic salicylaldehyde Schiff base zirconium complex. The cationic part is formed by coordination of zi

SnO2 nanoparticles: An efficient reusable heterogeneous catalyst for synthesis of 3,4-dihydropyrimidinones under solvent-free conditions

Some 3,4-dihydropyrimidine derivatives have been synthesized from the reaction of divergent aldehydes with acetylacetone and urea/thiourea using nano tin oxide nanoparticles under solvent-free condition. The nanoparticle catalyst used in this synthesis is