2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenyl-

Base Information

• Chemical Name: 2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenyl-
• CAS No.: 25652-50-0
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Hs Code.: 2933599090
• Mol file: 25652-50-0.mol

Synonyms:5-Acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one;5-Acetyl-6-methyl-4-phenyl-1,2,3,4-tetrahydropyrimidin-2-one;Ethanone, 1-(1,6-dihydro-2-hydroxy-4-methyl-6-phenyl-5-pyrimidinyl)-;2-Oxo-5-acetyl-6-methyl-4-phenyl-1,2,3,4-tetrahydropyrimidine;Pyrimidin-2(1H)-one, 3,4-dihydro-5-acetyl-6-methyl-4-phenyl-;

Chemical Property of 2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenyl-

Chemical Property:

• Melting Point: 233-236 °C
• Boiling Point: 383.034 °C at 760 mmHg
• PKA: 11.34±0.70(Predicted)
• Flash Point: 153.205 °C
• PSA: 58.20000
• Density: 1.153 g/cm³
• LogP: 2.56110
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

5-Acetyl-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenyl-

There total 17 articles about 2(1H)-Pyrimidinone,5-acetyl-3,4-dihydro-6-methyl-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzaldehyde (100-52-7) + urea (57-13-6) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (25652-50-0)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 100 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)01139-X

Reference yield: 97.0%

benzyl chloride (100-44-7) + urea (57-13-6) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (25652-50-0)

Guidance literature:

benzyl chloride; With bismuth(III) nitrate; tetrabutyl ammonium fluoride; at 80 ℃;

urea; acetylacetone; at 80 ℃;

DOI:10.1055/s-2005-861876

Reference yield: 96.0%

benzaldehyde (100-52-7) + thiourea (17356-08-0) + acetylacetone (123-54-6,81235-32-7) → 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (25652-50-0)

Guidance literature:

With bismuth(III) vanadate; In neat (no solvent); at 120 ℃; for 1.33333h; Green chemistry;

DOI:10.1007/s13738-016-0959-y

upstream raw materials:

benzaldehyde

urea

acetylacetone

1,1'-phenylmethanediyl-bis-urea

Downstream raw materials:

5-acetyl-1-ethyl-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one

5-acetyl-6-methyl-4-phenylpyrimidin-2(1H)-one

5-(2-bromoacetyl)-3,4-dihydro-6-methyl-4-phenyl-pyrimidin-2(1H)-one

5-(2-aminothiazol-4-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one