Technology Process of 3-[2-(4-bromophenyl)ethyl]cyclobutanone ethylene ketal
There total 4 articles about 3-[2-(4-bromophenyl)ethyl]cyclobutanone ethylene ketal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
benzene;
at 120 ℃;
for 20h;
DOI:10.1021/jo990878c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Zn-Cu; POCl3 / diethyl ether / 4 h / 20 °C / Heating
2: Zn; AcOH / 2.5 h / 20 - 120 °C
3: 91 percent / p-TsOH / benzene / 20 h / 120 °C
With
copper; toluene-4-sulfonic acid; acetic acid; zinc; trichlorophosphate;
In
diethyl ether; benzene;
1: Cycloaddition / 2: Dehalogenation / 3: Cyclization;
DOI:10.1021/jo990878c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / diethyl ether / 5 h / 20 °C / Heating
2: Zn-Cu; POCl3 / diethyl ether / 4 h / 20 °C / Heating
3: Zn; AcOH / 2.5 h / 20 - 120 °C
4: 91 percent / p-TsOH / benzene / 20 h / 120 °C
With
copper; toluene-4-sulfonic acid; acetic acid; zinc; trichlorophosphate;
In
diethyl ether; benzene;
1: Substitution / 2: Cycloaddition / 3: Dehalogenation / 4: Cyclization;
DOI:10.1021/jo990878c
