15451-32-8

Usage

Uses

Used in Organic Synthesis:
4-(4-Bromophenyl)but-1-ene is used as a key intermediate in the synthesis of organic compounds for various applications due to its reactive bromine atom and the presence of a butene chain, which allows for further chemical reactions and functional group transformations.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4-(4-Bromophenyl)but-1-ene is utilized as a building block chemical for the production of specific pharmaceuticals. Its unique structure contributes to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
4-(4-Bromophenyl)but-1-ene also finds application in the agrochemical industry, where it serves as a precursor in the synthesis of agrochemicals. Its use in this industry is crucial for the development of new pesticides and other agricultural chemicals.
Used in Materials Science:
In the field of materials science, 4-(4-Bromophenyl)but-1-ene is employed in the creation of novel materials with specific properties. Its integration into material formulations can lead to advancements in material performance and applications.
Safety Considerations:
Given its classification as a hazardous chemical, 4-(4-Bromophenyl)but-1-ene requires careful handling and adherence to proper safety protocols to mitigate risks associated with its strong odor and potential health hazards.

InChI:InChI=1/C10H11Br/c1-2-3-4-9-5-7-10(11)8-6-9/h2,5-8H,1,3-4H2

Upstream product

• 106-95-6 allyl bromide 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 75-11-6 diiodomethane 
• 589-87-7 1,4-bromoiodobenzene 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 25574-11-2 3-(4-bromophenyl)propanol 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 80793-25-5 3-(4-bromophenyl)propanal 
• 24850-33-7 allyltributylstanane 
• 591-87-7 Allyl acetate 
• 57477-93-7 hydrazone of p-bromobenzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 5467-74-3 4-Bromophenylboronic acid 
• 346713-20-0 allylsamarium bromide 

Downstream Products

• 23853-88-5 2-(4-But-3-enyl-phenyl)-propan-2-ol 
• 358642-61-2 p-bromo-[4-(trichlorosilyl)butyl]benzene 
• 876477-17-7 4-(4-bromo-phenyl)-1,2-epoxy-butane 
• 1086974-99-3 potassium 4-(but-3-enyl)phenyltrifluoroborate 
• 1228259-64-0 1-bromo-4-(5,5,6,6,7,7,8,8,8-nonafluoro-3-iodooctyl)benzene 
• 1228259-65-1 1-bromo-4-(5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,14-henicosafluoro-3-iodo-tetradecyl)benzene 
• 768-56-9 4-Phenylbut-1-ene 
• 41492-05-1 p-bromobutylbenzene 
• 17100-43-5 (4-(but-3-en-1-yl)phenyl)methanol 

Relevant academic research and scientific papers

Triflimide-Catalysed Rearrangement of N-(1-Trimethylsilyl)allylhydrazones Results in the Formation of Vinylsilanes and Cyclopropanes

A synthesis of terminal vinylsilanes by triflimide-catalysed rearrangement of N-(1-trimethylsilyl)allylhydrazones is reported. This protocol provides a convenient access to versatile olefinic building blocks through a traceless bond construction. Hydrazones derived from aromatic aldehydes give cis-cyclopropanes in an unexpected side-reaction.

Transition-metal-catalyzed sequential cross-coupling of bis(iodozincio)methane and -ethane with two different organic halides

Bis(iodozincio)methane, prepared from diiodomethane and zinc, reacts with an organic halide in the presence of a transition-metal catalyst to give an iodozinciomethylenated compound; this then reacts with another organic halide to form a C-C bond. The overall process connects two electrophiles with one carbon atom. Bis(iodozincio)ethane can also undergo this transformation, yielding a new stereogenic center. The asymmetric induction of this stereogenic center was investigated by using a chiral palladium catalyst.

Ni-Catalyzed Carboxylation of Aziridines en Route to β-Amino Acids

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

Controllable Isomerization of Alkenes by Dual Visible-Light-Cobalt Catalysis

We report herein that thermodynamic and kinetic isomerization of alkenes can be accomplished by the combination of visible light with Co catalysis. Utilizing Xantphos as the ligand, the most stable isomers are obtained, while isomerizing terminal alkenes over one position can be selectively controlled by using DPEphos as the ligand. The presence of the donor–acceptor dye 4CzIPN accelerates the reaction further. Transformation of exocyclic alkenes into the corresponding endocyclic products could be efficiently realized by using 4CzIPN and Co(acac)2 in the absence of any additional ligands. Spectroscopic and spectroelectrochemical investigations indicate CoI being involved in the generation of a Co hydride, which subsequently adds to alkenes initiating the isomerization.

In Situ Generated Gold Nanoparticles on Active Carbon as Reusable Highly Efficient Catalysts for a Csp3 ?Csp3 Stille Coupling

Gold nanoparticle catalysts are important in many industrial production processes. Nevertheless, for traditional Csp2-Csp2 cross-coupling reactions they have been rarely used and Pd catalysts usually give a superior performance. Herein we report that in situ formed gold metal nanoparticles are highly active catalysts for the cross coupling of allylstannanes and activated alkylbromides to form Csp3-Csp3 bonds. Turnover numbers up to 29 000 could be achieved in the presence of active carbon as solid support, which allowed for convenient catalyst recovery and reuse. The present study is a rare case where a gold metal catalyst is superior to Pd catalysts in a cross-coupling reaction of an organic halide and an organometallic reagent.

Umpolung of Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium-Catalyzed Allylic Alkylation

Palladium-catalyzed allylic alkylation of nonstabilized carbon nucleophiles is difficult and remains a major challenge. Reported here is a highly chemo- and regioselective direct palladium-catalyzed C-allylation of hydrazones, generated from carbonyls, as a source of umpolung unstabilized alkyl carbanions and surrogates of alkyl organometallic reagents. Contrary to classical allylation techniques, this umpolung reaction utilizes hydrazones prepared not only from aryl aldehydes but also from alkyl aldehydes and ketones as renewable feedstocks. This strategy complements the palladium-catalyzed coupling of unstabilized nucleophiles with allylic electrophiles by providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.

CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulators which may be used as medicaments

Compound, a liquid crystal display element and a liquid crystal composition

PROBLEM TO BE SOLVED: To provide a compound having a lower viscosity than a conventional linear-cyclic compound and having excellent compatibility with a liquid crystal composition, and to provide a liquid crystal composition and a liquid crystal display

BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA

The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12, X11, X12 and Sp1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.