3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

Base Information

Chemical Name:3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester
CAS No.:207445-00-9
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

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Chemical Property of 3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

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Technology Process of 3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

There total 1 articles about 3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2448-45-5
Cbz-D-Phe

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 207445-00-9
3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

Guidance literature:: With dmap; TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1248/cpb.46.697

Reference yield:

: 207445-00-9
3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

: 207445-03-2
((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / methanol

2: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

3: H₂ / Pd/C / methanol

4: Et₃N / CH₂Cl₂

5: TFA / CH₂Cl₂

6: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

With dmap; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.697

Reference yield:

: 207445-00-9
3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

: 3-{(R)-3-Phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionylamino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol

2: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

3: H₂ / Pd/C / methanol

With dmap; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.697