((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

Base Information

Chemical Name:((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester
CAS No.:207445-03-2
Molecular Formula:C₃₂H₄₀N₄O₉
Molecular Weight:624.691
Hs Code.:

((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

Synonyms:((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

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Chemical Property of ((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

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Technology Process of ((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

There total 6 articles about ((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 207445-03-2
((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

2: H₂ / Pd/C / methanol

3: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

4: H₂ / Pd/C / methanol

5: Et₃N / CH₂Cl₂

6: TFA / CH₂Cl₂

7: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

With dmap; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.697

Reference yield:

: 207445-00-9
3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

: 207445-03-2
((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / methanol

2: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

3: H₂ / Pd/C / methanol

4: Et₃N / CH₂Cl₂

5: TFA / CH₂Cl₂

6: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

With dmap; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.697

Reference yield:

: 3-((R)-2-Amino-3-phenyl-propionylamino)-propionic acid tert-butyl ester

: 207445-03-2
((S)-2-{(R)-1-[2-(4-tert-Butoxycarbonylmethoxy-phenylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidin-1-yl)-oxo-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

2: H₂ / Pd/C / methanol

3: Et₃N / CH₂Cl₂

4: TFA / CH₂Cl₂

5: water soluble carbodiimide hydrochloride, HOBt, DMAP, TEA / dimethylformamide / Ambient temperature

With dmap; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.697