3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester
• CAS No.: 80242-15-5
• Molecular Formula: C₂₂H₁₇NO₃
• Molecular Weight: 343.382
• Mol file: 80242-15-5.mol

Synonyms:3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester

Chemical Property of 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester

There total 4 articles about 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-phenacylisoquinolinium bromide (25131-60-6) + ethyl acrylate (140-88-5,9003-32-1) → 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester (80242-15-5)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform; water; at 20 ℃;

DOI:10.1016/j.ejmech.2011.02.066

Reference yield: 50.0%

2-phenacylisoquinolinium bromide (25131-60-6) + propynoic acid ethyl ester (623-47-2) → 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester (80242-15-5)

Guidance literature:

With triethylamine; In benzene; for 20h; Ambient temperature;

DOI:10.1021/je00027a033

Reference yield:

isoquinoline (119-65-3) → 3-benzoylpyrrolo[2,1-a]isoquinoline-1-carboxylic acid ethyl ester (80242-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 20 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / chloroform; water / 20 °C

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; chloroform; water;

DOI:10.1016/j.ejmech.2011.02.066

upstream raw materials:

2-phenacylisoquinolinium bromide

propynoic acid ethyl ester

isoquinoline

ethyl acrylate