(2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester

Base Information

Chemical Name:(2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester
CAS No.:245467-31-6
Molecular Formula:C₁₄H₁₉NO₃
Molecular Weight:249.31
Hs Code.:
Mol file:245467-31-6.mol

Synonyms:3-[4-(2-dimethylaminoethoxy)phenyl]acrylic acid methyl ester

Suppliers and Price of (2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2E)-3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-propenoicAcidMethylEster
50mg
$ 90.00

Total 2 raw suppliers

Chemical Property of (2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester

Chemical Property:

Melting Point:47-48 °C(Solv: ligroine (8032-32-4))
Boiling Point:372.0±27.0 °C(Predicted)
PKA:8.66±0.28(Predicted)
Density:1.078±0.06 g/cm3(Predicted)
Solubility.:Methanol

Purity/Quality:

99% ^*data from raw suppliers

(2E)-3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-propenoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2E)-3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester is used in the synthesis of novel benz[e]indoles as effectors for prodrugs. (2E)-3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester is an intermediate in the synthesis of Beloranib (B131280). Beloranib is a pharmaceutical drug that is currently being evaluated through biological studies for its potential to combat obesity.

Technology Process of (2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester

There total 2 articles about (2E)-3-[4-[2-(DiMethylaMino)ethoxy]phenyl]-2-propenoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

: 3943-97-3
methyl 4-hydroxycinnamate

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 245467-31-6
3-[4-(2-dimethylaminoethoxy)phenyl]acrylic acid methyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Reagent/catalyst; Temperature; Solvent;

Reference yield: 70.0%

: 3943-97-3
methyl 4-hydroxycinnamate

: 107-99-3
2-(dimethylamino)ethyl chloride

: 245467-31-6
3-[4-(2-dimethylaminoethoxy)phenyl]acrylic acid methyl ester

Guidance literature:: methyl 4-hydroxycinnamate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

2-(dimethylamino)ethyl chloride; In N,N-dimethyl-formamide; toluene; for 2h; Heating;
DOI:10.1021/jm990136b

Reference yield: 99.0%

: 245467-31-6
3-[4-(2-dimethylaminoethoxy)phenyl]acrylic acid methyl ester

: 98-80-6
phenylboronic acid

: 1380439-87-1
(Z)-methyl 3-(4-(2-(dimethylamino)ethoxy)phenyl)-3-phenylacrylate

Guidance literature:: With potassium fluoride; TEMPOL; palladium diacetate; propionic acid; at 20 ℃; for 24h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201108211