8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Base Information

Chemical Name:8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole
CAS No.:1456693-27-8
Molecular Formula:C₃₂H₄₀N₂O₃SSi
Molecular Weight:560.833
Hs Code.:

Synonyms:8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

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Chemical Property of 8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

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Technology Process of 8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

There total 15 articles about 8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73792-06-0
ethyl-4-amino-2-fluorobenzoate

: 1456693-27-8
8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Guidance literature:: Multi-step reaction with 13 steps

1.1: N,N-dimethyl-formamide / 20 h / 60 °C

2.1: acetic acid; Iodine monochloride / 3.67 h / 60 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: diisobutylaluminium hydride / toluene / 3 h / 0 °C

6.1: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

8.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 8 h / 65 °C / Inert atmosphere

9.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

10.1: caesium carbonate / tetrahydrofuran; methanol / 4 h / 20 °C

11.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / dichloromethane; water; toluene / 20 h / 20 °C

12.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

12.2: 0.75 h / 20 °C

13.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; Iodine monochloride; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; caesium carbonate; Dess-Martin periodane; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1456693-26-7
8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methylsulfonyl)-3,4-dihydropyrazino[1,2-a]indole

: 1456693-27-8
8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

Reference yield:

: 1456693-25-6
tert-butyl (2-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-isobutyryl-6-(methylsulfonyl)-1H-indol-1-yl)ethyl)carbamate

: 1456693-27-8
8-(((tert-butyldiphenylsilyl)oxy)methyl)-1-isopropyl-7-(methyl sulfonyl)-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

1.2: 0.75 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane;