1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

Base Information

Chemical Name:1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol
CAS No.:1456693-22-3
Molecular Formula:C₃₁H₃₉NO₆S₂Si
Molecular Weight:613.871
Hs Code.:

Synonyms:1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

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Chemical Property of 1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

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Technology Process of 1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

There total 9 articles about 1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 565-68-4
4-methylpent-1-yn-3-ol

: 1456693-21-2
N-(4-(((tert-butyldiphenylsilyl)oxy)methyl)-2-iodo-5-(methylsulfonyl)phenyl)methanesulfonamide

: 1456693-22-3
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 65 ℃; for 8h; Inert atmosphere;

Reference yield:

: 73792-06-0
ethyl-4-amino-2-fluorobenzoate

: 1456693-22-3
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: N,N-dimethyl-formamide / 20 h / 60 °C

2: acetic acid; Iodine monochloride / 3.67 h / 60 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5: diisobutylaluminium hydride / toluene / 3 h / 0 °C

6: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

8: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 8 h / 65 °C / Inert atmosphere

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; Iodine monochloride; diisobutylaluminium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1456693-19-8
N-(4-(hydroxymethyl)-2-iodo-5-(methylthio)phenyl)methanesulfonamide

: 1456693-22-3
1-(5-(((tert-butyldiphenylsilyl)oxy)methyl)-1,6-bis(methylsulfonyl)-1H-indol-2-yl)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 8 h / 65 °C / Inert atmosphere

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;