N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide
CAS No.:1033859-80-1
Molecular Formula:C₁₅H₁₆BrFN₂OS
Molecular Weight:371.273
Hs Code.:

Synonyms:N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

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Technology Process of N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

There total 1 articles about N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1033865-70-1
(2-bromothiazol-4-ylmethyl)(4-fluorophenyl)amine

: 3282-30-2
pivaloyl chloride

: 1033859-80-1
N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h; Product distribution / selectivity;

Reference yield: 51.0%

: 34803-66-2
1-(2-pyridyl)piperazine

: 1033859-80-1
N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

: 1033859-90-3
N-(4-fluorophenyl)-2,2-dimethyl-N-{[2-(4-pyridin-2-ylpiperazin-1-yl)-1,3-thiazol-4-yl]methyl}propanamide

Guidance literature:: 1-(2-pyridyl)piperazine; N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide; at 50 ℃; for 16h; Neat (no solvent);

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 36.0%

: 20980-22-7
N-(2-pyridinyl)piperazine

: 1033859-80-1
N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide

: 1033859-94-7
N-(4-fluorophenyl)-2,2-dimethyl-N-{[2-(4-pyrimidin-2-ylpiperazin-1-yl)-1,3-thiazol-4-yl]methyl}propanamide

Guidance literature:: N-(2-pyridinyl)piperazine; N-[(2-bromo-1,3-thiazol-4-yl)methyl]-N-(4-fluorophenyl)-2,2-dimethylpropanamide; In dimethyl sulfoxide; at 75 ℃; for 16h;

With sodium hydrogencarbonate; In water; dimethyl sulfoxide; ethyl acetate;