(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

Base Information

Chemical Name:(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate
CAS No.:1544739-74-3
Molecular Formula:C₃₀H₂₈F₅NO₆S
Molecular Weight:625.613
Hs Code.:

(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

Synonyms:(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

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Chemical Property of (5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

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Technology Process of (5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

There total 14 articles about (5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1544739-73-2
2-bromo-1-fluoro-5-(3-(methylsulfonyl)propoxy)-3-(trifluoromethyl)benzene

: 1544739-24-3
4-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester

: 1544739-74-3
(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In tetrahydrofuran; water; at 100 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 1544739-10-7
(4-bromo-5-vinyl-pyridin-2-yl)-bis-(4-methoxy-benzyl)-amine

: 1544739-74-3
(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 18.33 h / Reflux; Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 3 h / Reflux; Inert atmosphere

3.1: rhodium(II) acetate / dichloromethane / 0.25 h

3.2: 3 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: sulfuric acid; sodium nitrite / 2 h / 0 - 20 °C

6.1: silver carbonate / toluene / 110 °C / Inert atmosphere

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran; water / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With rhodium(II) acetate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; sulfuric acid; caesium carbonate; silver carbonate; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 1544739-72-1
1-fluoro-3-(3-(methylsulfonyl)propoxy)-5-(trifluoromethyl)benzene

: 1544739-74-3
(5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / 4 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran; water / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; bromine; acetic acid; In tetrahydrofuran; water;