2-(3-methylphenyl)pyrazine

Base Information

• Chemical Name: 2-(3-methylphenyl)pyrazine
• CAS No.: 1142346-68-6
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.214
• Mol file: 1142346-68-6.mol

Synonyms:2-(3-methylphenyl)pyrazine

Chemical Property of 2-(3-methylphenyl)pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-methylphenyl)pyrazine

There total 6 articles about 2-(3-methylphenyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloropyrazin (14508-49-7) + m-tolylboronic acid (17933-03-8) → 2-(3-methylphenyl)pyrazine (1142346-68-6)

Guidance literature:

2-chloropyrazin; m-tolylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 95 ℃; for 0.166667h; Inert atmosphere;

With potassium fluoride dihydrate; In water; toluene; at 95 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01190

Reference yield: 86.0%

1,4-pyrazine (290-37-9) + meta-bromotoluene (591-17-3) → 2-(3-methylphenyl)pyrazine (1142346-68-6)

Guidance literature:

With (tricyclohexylphosphine)gold(I) chloride; potassium tert-butylate; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.01.059

Reference yield: 81.0%

ethylenediamine (107-15-3,85404-18-8) + 3-Methylacetophenone (585-74-0) → 2-(3-methylphenyl)pyrazine (1142346-68-6)

Guidance literature:

With toluene-4-sulfonic acid; potassium iodide; In N,N-dimethyl acetamide; at 100 ℃; for 5.7h; Inert atmosphere; Electrochemical reaction;

DOI:10.1039/c8gc03786h

upstream raw materials:

1,4-pyrazine

meta-bromotoluene

m-tolylboronic acid

2-oxo-2-(m-tolyl)acetaldehyde

Refernces

• 1、 -. "Method for site-selective alkylation of Diazine-N-oxide using phosphonium ylides". Paragraph 0103-0109. . Retrieved 2021/04/06.
• 2、 Liu, Kun,Song, Chunlan,Wu, Jiarong,Deng, Yuqi,Tang, Shan,Lei, Aiwen. "Electrochemical oxidation synergizing with Br?nsted-acid catalysis leads to [4 + 2] annulation for the synthesis of pyrazines". supporting information. p. 765 - 769. Retrieved 2019/02/27.