Technology Process of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylic acid ethanolamine salt
There total 18 articles about (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylic acid ethanolamine salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
methanol;
for 40h;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: hydrogen / Raney nickel / 1,4-dioxane / 8 h / 60 °C / 30402 Torr
2.1: 3 h / 0 - 20 °C
3.1: trichlorophosphate / 0.5 h
3.2: 5 h / Reflux
3.3: pH 5 - 6 / Cooling with ice
4.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C
5.1: triethylamine / dichloromethane / 0.08 h
5.2: 2 h
6.1: N-Bromosuccinimide / ethanol / 1 h
6.2: 1 h
7.1: potassium carbonate; chloroacetic acid ethyl ester / 0.08 h
7.2: 2 h / 60 °C
8.1: sodium hydroxide; water / methanol / 1 h
8.2: pH 3 - 5 / Cooling with ice
9.1: hydrogenchloride / ethyl acetate / 1 h
10.1: sodium hydroxide / water; methanol / 0.25 h
11.1: methanol / 40 h
With
hydrogenchloride; N-Bromosuccinimide; water; hydrogen; potassium carbonate; chloroacetic acid ethyl ester; triethylamine; sodium hydroxide; trichlorophosphate;
palladium 10% on activated carbon;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 3 h / 0 - 20 °C
2.1: trichlorophosphate / 0.5 h
2.2: 5 h / Reflux
2.3: pH 5 - 6 / Cooling with ice
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C
4.1: triethylamine / dichloromethane / 0.08 h
4.2: 2 h
5.1: N-Bromosuccinimide / ethanol / 1 h
5.2: 1 h
6.1: potassium carbonate; chloroacetic acid ethyl ester / 0.08 h
6.2: 2 h / 60 °C
7.1: sodium hydroxide; water / methanol / 1 h
7.2: pH 3 - 5 / Cooling with ice
8.1: hydrogenchloride / ethyl acetate / 1 h
9.1: sodium hydroxide / water; methanol / 0.25 h
10.1: methanol / 40 h
With
hydrogenchloride; N-Bromosuccinimide; water; hydrogen; potassium carbonate; chloroacetic acid ethyl ester; triethylamine; sodium hydroxide; trichlorophosphate;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water; ethyl acetate;
![(R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylic acid](/Databaselist/images/loading.webp)
