METHYL D-2-(4-FLUOROPHENYL)GLYCINATE HCL

Base Information

• Chemical Name: METHYL D-2-(4-FLUOROPHENYL)GLYCINATE HCL
• CAS No.: 439213-22-6
• Molecular Formula: C9H10FNO2^.HCl
• Molecular Weight: 219.643
• Hs Code.: 2922499990
• Mol file: 439213-22-6.mol

Synonyms:Benzeneaceticacid, a-amino-4-fluoro-, methyl ester,hydrochloride, (aR)-(9CI);

Chemical Property of METHYL D-2-(4-FLUOROPHENYL)GLYCINATE HCL

Chemical Property:

• Vapor Pressure: 0.00325mmHg at 25°C
• Boiling Point: 278.6 °C at 760 mmHg
• Flash Point: 122.3 °C
• PSA: 52.32000
• LogP: 2.50080
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyld-2-(4-Fluorophenyl)glycinateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL D-2-(4-FLUOROPHENYL)GLYCINATE HCL

There total 1 articles about METHYL D-2-(4-FLUOROPHENYL)GLYCINATE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

methanol (67-56-1) + (R)-2-(4-fluorophenyl)glycine (93939-74-3) → methyl (R)-2-amino-2-(4-fluorophenyl)acetate hydrochloride (439213-22-6,42718-18-3)

Guidance literature:

With thionyl chloride; at 0 - 75 ℃; for 2h;

DOI:10.1016/j.ejmech.2018.01.032

Reference yield: 96.4%

methyl (R)-2-amino-2-(4-fluorophenyl)acetate hydrochloride (439213-22-6,42718-18-3) + (2S)-3-acetylthio-2-methylpropionic acid (76497-39-7) → methyl (R)-2-((S)-3-(acetylthio)-2-methylpropanamido)-2-(4-fluorophenyl)acetate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2018.01.032

Reference yield: 84.0%

methyl (R)-2-amino-2-(4-fluorophenyl)acetate hydrochloride (439213-22-6,42718-18-3) → (R)-2-amino-2-(4-fluorophenyl)ethanol (174770-74-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.09.009

upstream raw materials:

methanol

(R)-2-(4-fluorophenyl)glycine

Downstream raw materials:

methyl (R)-(4-fluorophenyl)-(2,2,2-trifluoracetylamino)-acetate

(R)-2-amino-2-(4-fluorophenyl)ethanol

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