2-cyclopropyl-3-phenylpropanenitrile

Base Information

• Chemical Name: 2-cyclopropyl-3-phenylpropanenitrile
• CAS No.: 1390632-77-5
• Molecular Formula: C₁₂H₁₃N
• Molecular Weight: 171.242
• Mol file: 1390632-77-5.mol

Synonyms:2-cyclopropyl-3-phenylpropanenitrile

Chemical Property of 2-cyclopropyl-3-phenylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclopropyl-3-phenylpropanenitrile

There total 1 articles about 2-cyclopropyl-3-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-cyclopropylacetonitrile (6542-60-5) + benzyl bromide (100-39-0) → 2-cyclopropyl-3-phenylpropanenitrile (1390632-77-5)

Guidance literature:

2-cyclopropylacetonitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

benzyl bromide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201406181

Reference yield: 86.0%

5-iodo-2-methylpent-2-ene (43161-11-1) + 2-cyclopropyl-3-phenylpropanenitrile (1390632-77-5) → 2-benzyl-2-cyclopropyl-6-methylhept-5-enenitrile

Guidance literature:

2-cyclopropyl-3-phenylpropanenitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

5-iodo-2-methylpent-2-ene; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.8b11840

Reference yield: 51.0%

2-cyclopropyl-3-phenylpropanenitrile (1390632-77-5) → 2-cyclopropyl-3-phenylpropan-1-amine (1226414-30-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 4.5h; Inert atmosphere; Reflux;

DOI:10.1021/ja305833a

upstream raw materials:

2-cyclopropylacetonitrile

benzyl bromide

Downstream raw materials:

2-cyclopropyl-3-phenylpropan-1-amine