trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate

Base Information

• Chemical Name: trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate
• CAS No.: 260366-88-9
• Molecular Formula: C₄₄H₅₅N₂O₇P
• Molecular Weight: 754.904

Synonyms:trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate

Chemical Property of trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate

There total 12 articles about trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl-{8-(bis-benzyloxy-phosphanyloxy)-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]dec-3-yl}-carbamic acid tert-butyl ester → trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-8-(dibenzylphosphoroxy)-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decane 1-oxide + trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate (260366-88-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate (260366-88-9)

Guidance literature:

Multi-step reaction with 11 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

5: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

6: 0.59 g / NaBH₄ / methanol / 0 - 20 °C

7: 79 percent / aq. HCl / tetrahydrofuran / 12 h / 20 °C

8: 75 percent / NaBH₄ / methanol / 0 - 20 °C

9: 76 percent / Et₃N / methanol / 5 h / 50 °C

10: 1-H-tetrazole / CH₂Cl₂ / 5 h / 20 °C

11: 0.41 g / MCPBA / CH₂Cl₂ / 2 h / 0 °C

With 1H-tetrazole; hydrogenchloride; sodium tetrahydroborate; silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation / 5: Condensation / 6: Reduction / 7: Hydrolysis / 8: Reduction / 9: Acylation / 10: phosphorylation / 11: Oxidation;

DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

4-Methoxyphenethylamine (55-81-2) → trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate (260366-88-9)

Guidance literature:

Multi-step reaction with 11 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

5: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

6: 0.59 g / NaBH₄ / methanol / 0 - 20 °C

7: 79 percent / aq. HCl / tetrahydrofuran / 12 h / 20 °C

8: 75 percent / NaBH₄ / methanol / 0 - 20 °C

9: 76 percent / Et₃N / methanol / 5 h / 50 °C

10: 1-H-tetrazole / CH₂Cl₂ / 5 h / 20 °C

11: 0.41 g / MCPBA / CH₂Cl₂ / 2 h / 0 °C

With 1H-tetrazole; hydrogenchloride; sodium tetrahydroborate; silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation / 5: Condensation / 6: Reduction / 7: Hydrolysis / 8: Reduction / 9: Acylation / 10: phosphorylation / 11: Oxidation;

DOI:10.1016/S0968-0896(99)00250-3

upstream raw materials:

cyclohexanedione monoethylene ketal

4-Methoxyphenethylamine

(1,4-dioxa-spiro[4.5]dec-8-ylidene)-[2-(4-methoxy-phenyl)-ethyl]-amine

4-allyl-4-[2-(4-methoxyphenyl)ethylamino]cyclohexanone ethylene acetal

Downstream raw materials:

trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dihydrogenphosphate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 260366-88-9 trans-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]dec-8-yl dibenzyl phosphate

Send

Send

Metric Ton KG G Pound L ML

Send

Send