(((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

Base Information

Chemical Name:(((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane
CAS No.:1381848-60-7
Molecular Formula:C₂₆H₄₅IO₄Si
Molecular Weight:576.631
Hs Code.:

Synonyms:(((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

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Chemical Property of (((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

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Technology Process of (((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

There total 6 articles about (((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1381848-59-4
tert-butyl(((2S,4S,5S,6S)-6-(2-((4-methoxybenzyl)oxy)ethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methoxy)dimethylsilane

: 1381848-60-7
(((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 3.75h;
DOI:10.1021/acs.joc.7b02293

Reference yield:

: C₁₈H₂₈O₃Si

: 1381848-60-7
(((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

Guidance literature:: Multi-step reaction with 6 steps

1.1: CrCl(C₆H₂(O)(C₁₀H₁₅)(CH₃)(CHNC₉H₈O)) / 20.5 h / 20 °C / Molecular sieve

2.1: potassium carbonate / methanol / 0.5 h / 20 °C

2.2: 20 °C

3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.67 h / -20 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

5.1: camphor-10-sulfonic acid / methanol; dichloromethane / 1 h / 0 °C

6.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium tetrahydroborate; CrCl(C₆H₂(O)(C₁₀H₁₅)(CH₃)(CHNC₉H₈O)); cerium(III) chloride heptahydrate; camphor-10-sulfonic acid; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol301278e

Reference yield:

: 1381848-54-9
C₂₆H₄₆O₅Si₂

: 1381848-60-7
(((2S,3S,4S,6S)-6-(iodomethyl)-2-(2-((4-methoxybenzyl)oxy)ethyl)-3-methyltetrahydro-2H-pyran-4-yl)oxy)triisopropylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / methanol / 0.5 h / 20 °C

1.2: 20 °C

2.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.67 h / -20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

4.1: camphor-10-sulfonic acid / methanol; dichloromethane / 1 h / 0 °C

5.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium tetrahydroborate; cerium(III) chloride heptahydrate; camphor-10-sulfonic acid; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol301278e