tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate
CAS No.:1036756-34-9
Molecular Formula:C₃₀H₃₆N₆O₃Si
Molecular Weight:556.74
Hs Code.:

Synonyms:tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

There total 3 articles about tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036756-33-8
tert-butyl 2-(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)ethylcarbamate

: 1066-54-2
trimethylsilylacetylene

: 1036756-34-9
tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 95 ℃;

Reference yield:

: 882672-05-1
6-bromo-2-chloroquinazoline

: 1036756-34-9
tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 95 - 100 °C

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 95 °C

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1202036-32-5
tert-butyl 2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)ethylcarbamate

: 1036756-34-9
tert-butyl 2-(3-(1-methyl-1H-pyrazol-4-yl)-5-(6-((trimethylsilyl)ethynyl)quinazolin-2-ylamino)phenoxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 95 - 100 °C

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 95 °C

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; isopropyl alcohol;