(S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:122778-49-8
Molecular Formula:C₁₅H₂₇ClO₂
Molecular Weight:274.831
Hs Code.:

Synonyms:(S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 3 articles about (S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 111070-64-5
(1R,3R,4S)-p-menthan-3-yl (2R)-2-hydroxymethylbutyrate

: 122778-49-8
(S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: With tetrachloromethane; triphenylphosphine; for 15h; Heating;

Reference yield:

: 2216-51-5
(-)-menthol

: 122778-49-8
(S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / dicyclohexylcarbodi-imide, 4-(N,N-dimethylamino)pyridine / acetonitrile; CH₂Cl₂ / -40 deg C, 6 h; room temperature, 10 h; oily substance was set aside for 5 days at room temperature

2: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

3: 98 percent / Ph₃P, CCl₄ / 15 h / Heating

With tetrachloromethane; dmap; oxalyl dichloride; tetrabutylammonium borohydride; dicyclohexyl-carbodiimide; triphenylphosphine; In dichloromethane; acetonitrile;

Reference yield:

: 111042-75-2
(1R,3R,4S)-p-menthan-3-yl hydrogen (R)-ethylmalonate

: 122778-49-8
(S)-2-Chloromethyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) oxalyl chloride, 2.) tetrabutylammonium borohydride / 1.) CH₂Cl₂, reflux, 2 h, 2.) -78 deg C, 30 min

2: 98 percent / Ph₃P, CCl₄ / 15 h / Heating

With tetrachloromethane; oxalyl dichloride; tetrabutylammonium borohydride; triphenylphosphine;