methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate

Base Information

• Chemical Name: methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate
• CAS No.: 908002-26-6
• Molecular Formula: C₂₁H₃₈O₄Si₂
• Molecular Weight: 410.701
• Mol file: 908002-26-6.mol

Synonyms:methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate

Chemical Property of methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate

There total 6 articles about methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 3-hydroxy-4-(hydroxymethyl)-benzoate (71780-40-0) + tert-butyldimethylsilyl chloride (18162-48-6) → methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate (908002-26-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 0.75h;

DOI:10.1021/ja062948k

Reference yield:

2-bromo-1,4-benzenedicarboxylic acid (586-35-6) → methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate (908002-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / sodium hydroxide; sodium acetate / Cu / H₂O / 80 h / Heating

2: 84 percent / sulfuric acid / 24 h / Heating

3: 75 percent / sodium borohydride / methanol / 1 h / 20 °C

4: 96 percent / imidazole / dimethylformamide / 0.75 h

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; sodium acetate; copper; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/ja062948k

Reference yield:

3-hydroxy-4-morpholin-4-ylmethylbenzoic acid methyl ester (87177-50-2) → methyl 3-tert-butyldimethylsilyloxy-4-(tert-butyldimethylsilyloxymethyl)benzoate (908002-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / acetonitrile / 80 °C

2: 96 percent / imidazole / dimethylformamide / 0.75 h

With 1H-imidazole; sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ja062948k

upstream raw materials:

methyl 3-hydroxy-4-(hydroxymethyl)-benzoate

tert-butyldimethylsilyl chloride

3-hydroxy-4-morpholin-4-ylmethylbenzoic acid methyl ester

2-hydroxyterephthalic acid

Downstream raw materials:

methyl 3-tert-butyldimethylsilyloxy-4-acetoxymethylbenzoate