5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER

Base Information

• Chemical Name: 5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER
• CAS No.: 103765-33-9
• Molecular Formula: C₉H₁₁NO₄S
• Molecular Weight: 229.257
• Hs Code.: 29349990
• Mol file: 103765-33-9.mol

Synonyms:2,4-Thiophenedicarboxylicacid, 5-amino-3-methyl-, dimethyl ester (9CI);2-Amino-3,5-dicarbomethoxy-4-methylthiophene;

Chemical Property of 5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER

Chemical Property:

• Vapor Pressure: 5.59E-05mmHg at 25°C
• Melting Point: 142-143 °C
• Refractive Index: 1.574
• Boiling Point: 346.9±37.0 °C at 760 mmHg
• Flash Point: 163.6±26.5 °C
• PSA: 106.86000
• Density: 1.3±0.1 g/cm³
• LogP: 1.79310
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Dimethyl5-Amino-3-methylthiophene-2,4-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: dimethyl 5-amino-3-methylthiophene-2,4-dicarboxylate is a useful reactant for the synthesis of fused pyrimidin-?4-?ones, and substituted thieno[2,?3-?d]?pyrimidin-?4(3H)?-?one derivatives.

Technology Process of 5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER

There total 1 articles about 5-AMINO-3-METHYL-THIOPHENE-2,4-DICARBOXYLIC ACID DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

acetoacetic acid methyl ester (105-45-3) + methyl 2-cyanoacetate (105-34-0) → 5-amino-3-methylthiophene-2,4-dicarboxylic acid dimethyl ester (103765-33-9)

Guidance literature:

With diethylamine; In tert-butyl alcohol; at 70 - 75 ℃; for 48h;

DOI:10.1021/ja953025k

Reference yield: 72.8%

formamide (77287-34-4,77287-35-5,60100-09-6) + 5-amino-3-methylthiophene-2,4-dicarboxylic acid dimethyl ester (103765-33-9) → ethyl 4-hydroxy-5 -methyl-thieno[2,3-d]pyrimidine-6-carboxylate (17417-67-3)

Guidance literature:

With acetic acid; at 150 ℃; for 40h;

upstream raw materials:

acetoacetic acid methyl ester

methyl 2-cyanoacetate

Downstream raw materials:

ethyl 4-hydroxy-5 -methyl-thieno[2,3-d]pyrimidine-6-carboxylate

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