Technology Process of (5S,6S,7R)-7-[4-(methoxybenzyl)oxy]-5-hydroxy-2,2,6,8-tetramethyl-3-nonanone
There total 7 articles about (5S,6S,7R)-7-[4-(methoxybenzyl)oxy]-5-hydroxy-2,2,6,8-tetramethyl-3-nonanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dimethylaluminum chloride;
In
dichloromethane;
at -78 ℃;
for 2h;
Title compound not separated from byproducts.;
DOI:10.1021/ja011337j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LiBH4 / tetrahydrofuran; methanol / 1 h / 0 °C
1.2: 79 percent / p-toluenesulfonic acid / CH2Cl2 / 2 h / 20 °C
2.1: 99 percent / DIBAL-H / toluene; CH2Cl2 / 1 h / 0 °C
3.1: 95 percent / oxalylchloride; DMSO; Et3N / CH2Cl2 / 0.92 h / -78 °C
4.1: Me2AlCl / CH2Cl2 / 2 h / -78 °C
With
lithium borohydride; Chloro-oxo-acetic acid; dimethylaluminum chloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
3.1: Swern oxidation / 4.1: Mukaiyama aldol reaction;
DOI:10.1021/ja011337j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / oxalylchloride; DMSO; Et3N / CH2Cl2 / 0.92 h / -78 °C
2: Me2AlCl / CH2Cl2 / 2 h / -78 °C
With
Chloro-oxo-acetic acid; dimethylaluminum chloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
1: Swern oxidation / 2: Mukaiyama aldol reaction;
DOI:10.1021/ja011337j
