tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate
CAS No.:1182402-94-3
Molecular Formula:C₃₆H₄₂ClFN₂O₈S
Molecular Weight:717.255
Hs Code.:

tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

Synonyms:tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

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Chemical Property of tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

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Technology Process of tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

There total 5 articles about tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188354-96-2,1188354-97-3,1182402-77-2
tert-Butyl 4-[3-[5-chloro-3-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidine-1-carboxylate

: 63624-28-2
2,4-dimethoxybenzenesulfonylchloride

: 1182402-94-3
tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

Guidance literature:: tert-Butyl 4-[3-[5-chloro-3-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidine-1-carboxylate; With potassium tert-butylate; In tetrahydrofuran; at -30 - 0 ℃;

2,4-dimethoxybenzenesulfonylchloride; In tetrahydrofuran; at -60 - 20 ℃;

Reference yield:

: 57486-67-6
methyl o-fluorophenylacetate

: 1182402-94-3
tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -20 - 3 °C

2.1: acetic acid; iron / methanol / 16 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / -40 - -15 °C / Inert atmosphere

3.2: 16 h / -50 - 12 °C

4.1: potassium tert-butylate / tetrahydrofuran / -30 - 0 °C

4.2: -60 - 20 °C

With potassium tert-butylate; iron; sodium hydride; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 84478-76-2
1-chloro-5-fluoro-2-methoxy-4-nitrobenzene

: 1182402-94-3
tert-butyl 4-[3-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-fluoro-phenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidin-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -20 - 3 °C

2.1: acetic acid; iron / methanol / 16 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / -40 - -15 °C / Inert atmosphere

3.2: 16 h / -50 - 12 °C

4.1: potassium tert-butylate / tetrahydrofuran / -30 - 0 °C

4.2: -60 - 20 °C

With potassium tert-butylate; iron; sodium hydride; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;