imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

Base Information

Chemical Name:imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide
CAS No.:1067191-58-5
Molecular Formula:C₂₇H₂₈N₄O₄
Molecular Weight:472.544
Hs Code.:

Synonyms:imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

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Chemical Property of imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

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Technology Process of imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

There total 4 articles about imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1067192-41-9
N-[4-(2-amino-1,1-dimethyl-ethyl)-phenyl]-3,4-dimethoxy-benzamide

: 6200-60-8
imidazo[1,2-a]pyridine-3-carboxylic acid

: 1067191-58-5
imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

Guidance literature:: imidazo[1,2-a]pyridine-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

N-[4-(2-amino-1,1-dimethyl-ethyl)-phenyl]-3,4-dimethoxy-benzamide; With triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1067189-44-9
ADX₆₁₆₂₃

: 1067191-58-5
imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 15 h / 20 °C / 2475.25 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 16 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 115279-57-7
2-(4-aminophenyl)-2-methylpropionitrile

: 1067191-58-5
imidazo[1,2-a]pyridine-3-carboxylic acid {2-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-2-methyl-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 15 h / 20 °C / 2475.25 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 16 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;