2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

Base Information

Chemical Name:2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide
CAS No.:912675-37-7
Molecular Formula:C₂₆H₂₉N₅O
Molecular Weight:427.549
Hs Code.:

Synonyms:2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

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Chemical Property of 2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

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Technology Process of 2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

There total 5 articles about 2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 905971-61-1
[2-(adamant-1-yl)-5-phenyl-1H-pyrrol-1-yl]acetic acid

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 912675-37-7
2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

Guidance literature:: [2-(adamant-1-yl)-5-phenyl-1H-pyrrol-1-yl]acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 5h;

1H-pyrazole-1-carboximidamide hydrochloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm0607451

Reference yield:

: 905971-60-0
4-(adamantan-1-yl)-2-benzoyl-4-oxo-butyric acid ethyl ester

: 912675-37-7
2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 356 mg / aq. NaOH / ethanol / 16 h / 110 °C

2.1: 57 percent / AcOH / Heating

3.1: carbonyldiimidazole / CH₂Cl₂ / 5 h / 20 °C

3.2: Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 18 h / 20 °C

With sodium hydroxide; acetic acid; 1,1'-carbonyldiimidazole; In ethanol; dichloromethane;
DOI:10.1021/jm0607451

Reference yield:

: 5122-82-7
1-adamantyl bromomethyl ketone

: 912675-37-7
2-(2-adamantan-1-yl-5-phenylpyrrol-1-yl)-N-(aminopyrazol-1-ylmethylene)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 4 h / 0 °C

2.1: 356 mg / aq. NaOH / ethanol / 16 h / 110 °C

3.1: 57 percent / AcOH / Heating

4.1: carbonyldiimidazole / CH₂Cl₂ / 5 h / 20 °C

4.2: Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 18 h / 20 °C

With sodium hydroxide; sodium hydride; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm0607451