3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

Base Information

• Chemical Name: 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt
• CAS No.: 197515-02-9
• Molecular Formula: C₂₅H₁₈F₃N₃O₂
• Molecular Weight: 449.432
• Mol file: 197515-02-9.mol

Synonyms:3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

Chemical Property of 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

There total 4 articles about 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-(trifluoromethyl)phenylhydrazine (368-90-1) + 4-hydroxy-2-(4-methoxy-benzyl)-1,2-dihydro-isoquinoline-3-carboxylic acid methyl ester → 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt (197515-02-9)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In ethanol; for 18h; Heating;

DOI:10.1021/jo034160f

Reference yield:

methyl 2-bromomethylbenzoate (2417-73-4) → 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt (197515-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / Et₃N / diethyl ether / 16 h / Heating

2: 81 percent / t-BuOH; NaH / toluene / 12 h / Heating

3: 48 percent / 4-toluenesulfonic acid hydrate / ethanol / 18 h / Heating

With p-toluenesulfonic acid monohydrate; sodium hydride; triethylamine; tert-butyl alcohol; In diethyl ether; ethanol; toluene;

DOI:10.1021/jo034160f

Reference yield:

(4-methoxybenzylamino)acetic acid methyl ester (20839-80-9) → 3-hydroxy-4-[(4-methoxyphenyl)methyl]-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt (197515-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / Et₃N / diethyl ether / 16 h / Heating

2: 81 percent / t-BuOH; NaH / toluene / 12 h / Heating

3: 48 percent / 4-toluenesulfonic acid hydrate / ethanol / 18 h / Heating

With p-toluenesulfonic acid monohydrate; sodium hydride; triethylamine; tert-butyl alcohol; In diethyl ether; ethanol; toluene;

DOI:10.1021/jo034160f

upstream raw materials:

4-(trifluoromethyl)phenylhydrazine

methyl 2-bromomethylbenzoate

(4-methoxybenzylamino)acetic acid methyl ester

methyl 2-{N-(methoxycarbonylmethyl)-N-[(4-methoxyphenyl)methyl]aminomethyl}benzoate

Downstream raw materials:

3-hydroxy-4-methoxycarbonylmethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

3-hydroxy-4-ethyl-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinolinium inner salt

3-hydroxy-2-(4-trifluoromethylphenyl)-2H-pyrazolo[4,3-c]isoquinoline