((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester

Base Information

• Chemical Name: ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester
• CAS No.: 101250-58-2
• Molecular Formula: C₂₀H₃₂N₂O₄
• Molecular Weight: 364.485

Synonyms:((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester

Chemical Property of ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester

Chemical Property:

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Technology Process of ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester

There total 3 articles about ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(2-Methylpropyl)-aziridine (23852-57-5) → ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester (101250-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.5 percent / Et₃N / diethyl ether / 1 h / 0 °C

2: 17.6 g / ethanol / 48 h / Heating

With triethylamine; In diethyl ether; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester (101250-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.5 percent / Et₃N / diethyl ether / 1 h / 0 °C

2: 17.6 g / ethanol / 48 h / Heating

With triethylamine; In diethyl ether; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

Glycine tert-butyl ester (6456-74-2) + (S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate (101250-56-0) → ((S)-2-Benzyloxycarbonylamino-4-methyl-pentylamino)-acetic acid tert-butyl ester (101250-58-2) + *,R*)>-1,1-dimethylethyl N,N-bis<4-methyl-2-<<(phenylmethoxy)carbonyl>amino>pentyl>glycinate (101250-57-1)

Guidance literature:

In ethanol; for 48h; Heating;

DOI:10.1021/jm00156a012

upstream raw materials:

Glycine tert-butyl ester

(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

(S)-2-(2-Methylpropyl)-aziridine

benzyl chloroformate

Downstream raw materials:

*,R^*)>-phenylmethyl 2-<<<1-<<(2-amino-2-oxoethyl)amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

*,R^*)>-N-<4-methyl-2-<<<1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinyl>methyl>amino>pentyl>glycine

*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

[tert-Butoxycarbonyl-((S)-4-methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentyl)-amino]-acetic acid tert-butyl ester

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