[S-(R,R)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Base Information

Chemical Name:[S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester
CAS No.:101250-84-4
Molecular Formula:C₂₂H₃₃N₃O₅
Molecular Weight:419.521
Hs Code.:

Synonyms:[S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

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Chemical Property of [S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

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Technology Process of [S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

There total 6 articles about [S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [S-(R*,R*)]-2-[[[1-[[[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

: 101250-84-4
[S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate;

Reference yield:

: 23852-57-5
(S)-2-(2-Methylpropyl)-aziridine

: 101250-84-4
[S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90.5 percent / Et₃N / diethyl ether / 1 h / 0 °C

2: 17.6 g / ethanol / 48 h / Heating

3: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

4: 1H-benzotriazol-1-ol (HOBT), DCC / tetrahydrofuran / 18 h / 25 °C

5: HCl gas / 1.) 25 deg C, 4 h, 2.) 0 deg C, 18 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol;
DOI:10.1021/jm00156a012

Reference yield:

: 101250-56-0
(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

: 101250-84-4
[S-(R*,R*)]-2-[[[1-[[(2-methoxy-2-oxoethyl)amino]methyl]-3-methylbutyl]amino]carbonyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 1H-benzotriazol-1-ol (HOBT), DCC / tetrahydrofuran / 18 h / 25 °C

4: HCl gas / 1.) 25 deg C, 4 h, 2.) 0 deg C, 18 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm00156a012