N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine
CAS No.:606926-42-5
Molecular Formula:C₁₃H₁₄F₃NO₅S₂
Molecular Weight:385.385
Hs Code.:

Synonyms:N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

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Technology Process of N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

There total 6 articles about N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 33439-27-9
N-tosyl-4-piperidone

: 606926-42-5
N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

Guidance literature:: N-tosyl-4-piperidone; With pyridine; In dichloromethane; for 0.333333h; Cooling with ice;

trifluoromethylsulfonic anhydride; In dichloromethane; at 40 ℃; for 10h; Reagent/catalyst; Solvent; Temperature; Cooling with ice;

Reference yield: 80.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 33439-27-9
N-tosyl-4-piperidone

: 606926-42-5
N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(03)00824-X

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 606926-42-5
N-(4-methylphenylsulfonyl)-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water; chloroform / 48 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

2.2: 17 h / 20 °C / Inert atmosphere

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; water;
DOI:10.1021/acs.orglett.0c02020