115012-52-7

Upstream product

• 119836-08-7 1-(2-fluorophenyl)piperidin-4-ol 
• 115012-46-9 1-(2-fluorophenyl)piperidin-4-one 
• 3592-25-4 1,5-dichloropentan-3-one 
• 348-54-9 2-Fluoroaniline 
• 115012-48-1 1-(2-fluorophenyl)-4,4-dimethoxypiperidine 

Downstream Products

• 131474-62-9 1-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 164300-63-4 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-N-1,N-3-bis(pivaloyloxymethyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)pseudouridine 
• 171503-89-2 1-((2R,3R,3aS,9aR)-3-{2-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-ethyl}-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione 
• 171503-89-2 1-((2R,3R,3aS,9aR)-3-{2-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-ethyl}-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-hydroxy-1H-pyrimidin-2-one 
• 195247-15-5 2,2-Dimethyl-propionic acid 3-{(2R,3R,3aR,9aR)-3-[1-(2-fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 160905-64-6 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)-6-N-pivaloyladenosine 
• 160905-68-0 4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine 
• 160905-78-2 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)cytidine 
• 160905-67-9 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyladenosine 
• 160905-74-8 4-N-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>cytidine 
• 147490-71-9 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyladenosine 
• 147490-72-0 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>cytidine 
• 199480-65-4 C₆₀H₆₆FN₆O₁₉P 
• 1055029-95-2 C₆₀H₆₆FN₆O₁₈P 

Relevant academic research and scientific papers

Facile preparation of acetals and enol ethers derived from 1-arylpiperidin-4-ones

When primary aromatic amines 6 are heated under reflux with slight excesses each of crude 1,5-dichloro-pentan-3-one 4 and toluene-4-sulfonic acid monohydrate in dry methanol solution, and an excess of trimethyl orthoformate is then added to the reactants,

A New Synthesis of 1-Arylpiperidin-4-ols

1,5-Dichloropentan-3-ol (8), which is readily prepared from the corresponding ketone (7), reacts with 2-fluoro-, 4-methyl-, 2-chloro-, 3-chloro-, 4-chloro-, and 3-chloro-4-methyl-anilines in the presence of potassium carbonate and sodium iodide in dimethy