ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate

Base Information

• Chemical Name: ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate
• CAS No.: 697762-43-9
• Molecular Formula: C₁₄H₁₅FINO₃
• Molecular Weight: 391.181
• Mol file: 697762-43-9.mol

Synonyms:ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate

Chemical Property of ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate

There total 7 articles about ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-fluoro-5-iodobenzoyl chloride (186584-73-6) + ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) → ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate (697762-43-9)

Guidance literature:

With triethylamine; In toluene; at 20 - 90 ℃; for 6h;

DOI:10.1016/j.bmc.2010.06.050

Reference yield: 66.0%

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) → ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate (697762-43-9)

Guidance literature:

2-fluoro-5-iodobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 20 ℃; for 3h;

ethyl 3-(dimethylamino)acrylate; With triethylamine; In chloroform; at 20 ℃; for 15h;

Reference yield:

2-fluoro-5-iodobenzoyl chloride (186584-73-6) + ethyl (2Z)-3-(dimethylamino)prop-2-enoate (114894-59-6) → ethyl 3-(dimethylamino)-2-[(2-fluoro-5-iodophenyl)carbonyl]-2-propenoate (697762-43-9)

Guidance literature:

With triethylamine; In toluene; at 90 ℃; for 1h;

upstream raw materials:

2-fluoro-5-iodobenzoyl chloride

ethyl 3-(dimethylamino)acrylate

2-fluoro-5-iodobenzoic acid

o-fluoro-benzoic acid

Downstream raw materials:

C₁₈H₂₃FINO₄

ethyl 3-tert-butylamino-2-(2-fluoro-5-iodo-benzoyl)-2-propenoate

ethyl 3-dimethylamino-2-{5-[3-(tert-butoxycarbonylamino)propyn-1-yl]-2-fluorobenzoyl}-2-propenoate

1-ethyl-4-oxo-6-[3-({2-[(phenylmethyl)oxy]ethyl}oxy)-1-propyn-1-yl]-1,4-dihydro-3-quinolinecarboxylic acid