Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Name:Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:500776-02-3
Molecular Formula:C₄₄H₅₄N₇O₇PS
Molecular Weight:855.995
Hs Code.:

Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 5 articles about Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.4%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 500775-96-2
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

: 500776-02-3
Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; at 20 ℃; for 1h;
DOI:10.1081/NCN-120023015

Reference yield:

: 40615-35-8
4,4'-dimethoxytrityl alcohol

: 500776-02-3
Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂S; CHCl₂COOH / CH₂Cl₂ / 1.25 h

2: 45 percent / 1,1,3,3-tetramethylguanidine / dimethylsulfoxide / 3 h / 20 °C

3: 72 percent / iPr₂NEt / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

With dichloro-acetic acid; hydrogen sulfide; N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylguanidine; In dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/hlca.200490252

Reference yield:

: 263746-51-6
4,4'-dimethoxytriphenylmethanethiol

: 500776-02-3
Diisopropyl-phosphoramidous acid (2S,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanylmethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / 1,1,3,3-tetramethylguanidine / dimethylsulfoxide / 3 h / 20 °C

2: 72 percent / iPr₂NEt / acetonitrile; CH₂Cl₂ / 1 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylguanidine; In dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/hlca.200490252