benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate

Base Information

• Chemical Name: benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate
• CAS No.: 1443227-28-8
• Molecular Formula: C₂₃H₁₉N₅O₂
• Molecular Weight: 397.436
• Mol file: 1443227-28-8.mol

Synonyms:benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate

Chemical Property of benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate

There total 3 articles about benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tryptamine (61-54-1) + benzyl (4-formylpyrimidin-2-yl)carbamate (1312764-26-3) → benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate (1443227-28-8)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 48h; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.05.026

Reference yield:

4-(dimethoxymethyl)pyrimidin-2-amine (165807-05-6) → benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate (1443227-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; ethanol / 0.25 h

1.2: 12 h / 5 - 10 °C

2.1: hydrogenchloride / water / 5 h / 20 °C

3.1: trifluoroacetic acid / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydrogencarbonate; trifluoroacetic acid; In ethanol; water; 3.1: |Pictet-Spengler Synthesis;

DOI:10.1016/j.tetlet.2013.05.026

Reference yield:

benzyl (4-(dimethoxymethyl)pyrimidin-2-yl)carbamate (1312764-25-2) → benzyl (4-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)pyrimidin-2-yl)carbamate (1443227-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 5 h / 20 °C

2: trifluoroacetic acid / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; trifluoroacetic acid; In water; 2: |Pictet-Spengler Synthesis;

DOI:10.1016/j.tetlet.2013.05.026

upstream raw materials:

tryptamine

benzyl (4-formylpyrimidin-2-yl)carbamate

4-(dimethoxymethyl)pyrimidin-2-amine

benzyl (4-(dimethoxymethyl)pyrimidin-2-yl)carbamate