(S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Base Information

Chemical Name:(S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate
CAS No.:1430738-25-2
Molecular Formula:C₂₇H₄₂N₂O₆Si
Molecular Weight:518.726
Hs Code.:

Synonyms:(S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

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Chemical Property of (S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

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Technology Process of (S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

There total 18 articles about (S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

: 1430738-24-1
(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

: 1430738-25-2
(S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 22 ℃; for 1h; Large scale;
DOI:10.1021/acs.oprd.8b00205

Reference yield:

: 1430738-06-9
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoyl)-4, 5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate

: 1430738-25-2
(S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

2: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

3: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

4: acetic acid / tetrahydrofuran; water / 3 h / 20 °C

With pyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; triphenyl-arsane; acetic acid; silver(l) oxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1: |Suzuki Coupling;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-25-2
(S)-allyl (2-(2-(hydroxymethyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

3: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

4: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

5: acetic acid / tetrahydrofuran; water / 3 h / 20 °C

With pyridine; 2,6-dimethylpyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; triphenyl-arsane; acetic acid; silver(l) oxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Suzuki Coupling;