(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Base Information

Chemical Name:(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate
CAS No.:1430738-24-1
Molecular Formula:C₃₃H₅₆N₂O₆Si₂
Molecular Weight:632.988
Hs Code.:

(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Synonyms:(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

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Chemical Property of (S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

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Technology Process of (S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

There total 18 articles about (S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1430738-23-0
(S)-(2-amino-5-methoxy-4-((triisopropylsilyl)oxy)phenyl) ( 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrol-1-yl)methanone

: 2937-50-0
Allyl chloroformate

: 1430738-24-1
(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Guidance literature:: With pyridine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/acsmedchemlett.6b00062

Reference yield:

: 1430738-06-9
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoyl)-4, 5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate

: 1430738-24-1
(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

2: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

3: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

With pyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; triphenyl-arsane; silver(l) oxide; zinc; In 1,4-dioxane; ethanol; dichloromethane; 1: |Suzuki Coupling;

Reference yield:

: 1430738-05-8
(S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropyls11yl)oxy)benzoyl)pyrrolidin-3-one

: 1430738-24-1
(S)-allyl (2-(2-(((tert-butyldimethylsilyl)oxy)methyl)-4-methyl-2,3-dihydro-1H-pyrrole-1-carbonyl)-4-methoxy-5-((triisopropylsilyl)oxy)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.5 h / -50 °C

2: potassium phosphate; triphenyl-arsane; silver(l) oxide; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere

3: zinc; formic acid / ethanol / 0.5 h / 30 °C / Cooling with ice

4: pyridine / dichloromethane / 0.5 h / -78 - 20 °C

With pyridine; 2,6-dimethylpyridine; potassium phosphate; bis(benzonitrile)palladium(II) dichloride; formic acid; triphenyl-arsane; silver(l) oxide; zinc; In 1,4-dioxane; ethanol; dichloromethane; 2: |Suzuki Coupling;