N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine

Base Information

• Chemical Name: N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine
• CAS No.: 73274-27-8
• Molecular Formula: C₁₁H₁₃Cl₂NO₂
• Molecular Weight: 262.136
• Mol file: 73274-27-8.mol

Synonyms:N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine

Chemical Property of N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine

There total 2 articles about N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dichlorobenzaldehyde (6287-38-3) + 2,2-dimethoxyethylamine (22483-09-6) → N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine (73274-27-8)

Guidance literature:

In toluene; for 1.5h; Heating;

DOI:10.1021/jo01298a038

Reference yield: 100.0%

3,4-dichlorobenzaldehyde (6287-38-3) + 2,2-dimethoxyethylamine (22483-09-6) → [1-(3,4-Dichloro-phenyl)-meth-(Z)-ylidene]-(2,2-dimethoxy-ethyl)-amine (73274-27-8)

Guidance literature:

In benzene; Heating;

DOI:10.1021/jm00179a007

Reference yield: 91.0%

acetic anhydride (108-24-7) + N-<(3,4-dichlorophenyl)methylene>-2,2-dimethoxyethanamine (73274-27-8) → N-(3,4-dichlorobenzyl)-N-(2,2-dimethoxyethyl)acetamide (73261-80-0)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; for 1h; under 1034.3 Torr;

DOI:10.1021/jo01298a038

upstream raw materials:

3,4-dichlorobenzaldehyde

2,2-dimethoxyethylamine

Downstream raw materials:

N-(3,4-dichlorobenzyl)-N-(2,2-dimethoxyethyl)acetamide

(3,4-dichlorobenzyl)(2,2-dimethoxyethyl)amine

1-(3,4-Dichloro-benzyl)-1,3-dihydro-imidazole-2-thione

6,7-dichloro-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 Briet, Nicolas,Brookes, Michael H,Davenport, Richard J,Galvin, Frances C.A,Gilbert, Philip J,Mack, Stephen R,Sabin, Verity. "Synthesis of novel substituted isoquinolones". . p. 5761 - 5766. Retrieved 2007/10/03.
• 2、 Perchonock,Lantos,Finkelstein,Holden. "Facile synthesis of halo-substituted tetrahydroisoquinolines and tetrahydro-2-benzazepines via N-acetyl-1,2-dihydroisoquinolines". . p. 1950 - 1953. Retrieved 2007/10/02.