2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Base Information

• Chemical Name: 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate
• CAS No.: 88981-61-7
• Molecular Formula: C₂₅H₂₄Cl₄N₂O₅S
• Molecular Weight: 606.354
• Mol file: 88981-61-7.mol

Synonyms:2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Chemical Property of 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

There total 3 articles about 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

((E)-5-Chloro-pent-4-enyl)-[1-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-meth-(E)-ylidene]-amine (84960-65-6) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate (88981-61-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chlorobenzene; at 120 ℃;

DOI:10.1021/ja00345a081

Reference yield:

N-<(4-methoxyphenyl)sulfonyl>-2-methylindole-3-carboxaldehyde (80664-26-2) → 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate (88981-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 4A molecular sieves

2: 50 percent / N(i-Pr)2Et / chlorobenzene / 120 °C

With 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; In chlorobenzene;

DOI:10.1021/ja00345a081

Reference yield:

(E)-1-<(p-methoxyphenyl)sulfonyl>-2-methyl-3-indole (84960-65-6) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-5α-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate (88981-61-7)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/ja00319a034

upstream raw materials:

((E)-5-Chloro-pent-4-enyl)-[1-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-meth-(E)-ylidene]-amine

2,2,2-Trichloroethyl chloroformate

(E)-1-<(p-methoxyphenyl)sulfonyl>-2-methyl-3-indole

N-<(4-methoxyphenyl)sulfonyl>-2-methylindole-3-carboxaldehyde

Downstream raw materials:

(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(R),5(R),6,7,11c(S)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(S),5(S),6,7,11c(R)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

(-)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(p-tolylthio)-20,21-dinoraspidospermidin-10-one