dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Base Information

Chemical Name:dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]
CAS No.:807341-87-3
Molecular Formula:C₄₇H₆₀N₄O₈
Molecular Weight:809.015
Hs Code.:

dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Synonyms:dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

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Chemical Property of dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

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Technology Process of dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

There total 5 articles about dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 807341-86-2
tert-butyl {3-[3-(3-aminopropyl)-5-(hydroxymethyl)phenyl]propyl}carbamate

: 210355-24-1
3,5-Bis-(3-benzyloxycarbonylamino-propyl)-benzoic acid

: 807341-87-3
dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Guidance literature:: 3,5-Bis-(3-benzyloxycarbonylamino-propyl)-benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -30 ℃;

tert-butyl {3-[3-(3-aminopropyl)-5-(hydroxymethyl)phenyl]propyl}carbamate; With triethylamine; In methanol; dichloromethane; at -20 - 20 ℃;
DOI:10.1002/hlca.200690246

Reference yield:

: 870177-64-3
ethyl 3-bromo-5-{3-{[(benzyloxy)carbonyl]amino}propyl}benzoate

: 807341-87-3
dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-BBN / toluene / 12 h / 20 °C

1.2: 86 percent / aq. KOH / Pd(PPh₃)4 / toluene / 14 h / 100 °C

2.1: 81 percent / LiAlH₄ / tetrahydrofuran / 8.5 h / cooling

3.1: 92 percent / H₂; cyclohexa-1,4-diene / Pd/C / ethanol; ethyl acetate / 4 h / 20 °C / 2250.18 Torr

4.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / -30 °C

4.2: 69 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

With lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; cyclohexa-1,4-diene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene; 1.2: Suzuki-Miyaura cross-coupling;
DOI:10.1002/hlca.200690246

Reference yield:

: 807341-84-0
benzyl tert-butyl {[5-(hydroxymethyl)-1,3-phenylene]dipropane-3,1-diyl}bis[carbamate]

: 807341-87-3
dibenzyl {{5-{{{{3-{3-{[(tert-butoxy)carbonyl]amino}propyl}-5-(hydroxymethyl)phenyl}propyl}amino}carbonyl}-1,3-phenylene}dipropane-3,1-diyl}bis[carbamate]

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / H₂; cyclohexa-1,4-diene / Pd/C / ethanol; ethyl acetate / 4 h / 20 °C / 2250.18 Torr

2.1: HOBt; N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl / CH₂Cl₂ / -30 °C

2.2: 69 percent / Et₃N / methanol; CH₂Cl₂ / -20 - 20 °C

With cyclohexa-1,4-diene; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1002/hlca.200690246